Gu Yunlan, the supreme master of the Divine Physician Hall from the modern era, transmigrates into the body of an illegitimate daughter in the Qi Dynasty. On her wedding night, she is married to Mu Chenye, the third son of the Mu family, who is rumored to be both foolish and lame. The Mu family’s second and fourth sons, Mu Wencheng and Mu Zixuan, attempt to assault her. When she resists, they kill her original body and then murder Mu Chenye by suffocation. Gu Yunlan awakens in the dying man’s body, utilizing her medical expertise and a mystical jade bracelet space to perform emergency acupuncture, saving Mu Chenye from death.
When the Mu family patriarch, Mu Kangsheng, arrives with the imperial physician, Gu Yunlan exposes the crimes of Mu Wencheng and Mu Zixuan. She presents physical evidence, including a bite mark on Mu Wencheng’s neck, and forces a confession. Mu Kangsheng, who genuinely loves his disabled son, punishes the two younger sons with severe beatings. Gu Yunlan establishes her authority in the household by disciplining the abusive servants in Mu Chenye’s courtyard, restructuring their ranks to ensure loyalty and efficiency. She begins a rigorous treatment regimen for Mu Chenye, using acupuncture to clear the toxins poisoning his body, which are the root cause of his cognitive and physical disabilities.
Three days after the wedding, Gu Yunlan takes Mu Chenye to her natal home, the Gu residence, for the traditional return visit. She is met with hostility and humiliation. Her father, Gu Xiude, a corrupt official who sold his daughter into the marriage for a promotion, and her stepmother, Wu Huanmei, along with her favored half-sister Gu Jiaojiao, treat her with disdain. Gu Jiaojiao orders Gu Yunlan to clean her pet dog’s choking hazard with her mouth. Gu Yunlan refuses and publicly humiliates her family, exposing Gu Xiude’s greed, Wu Huanmei’s neglect of her own son Gu Ziming, and Gu Jiaojiao’s malicious abuse of the original owner. The confrontation escalates when Gu Ziming, enraged by the public shaming, attacks Mu Chenye with a rock, causing a severe head wound.
Gu Yunlan performs emergency surgery on Mu Chenye in a locked room, stitching the wound and removing blood clots from his brain to save his life. During the procedure, she is interrupted by Dugu Yue, the founder of the Divine Physician Valley and the legendary ancestor of her own medical lineage. Recognizing her skills, Dugu Yue accepts her as his disciple and provides her with celestial iron acupuncture needles. These needles accelerate Mu Chenye’s recovery, and he eventually regains his cognitive faculties, shedding his foolish persona to reveal a sharp and calculating mind.
While Gu Yunlan manages the medical and domestic affairs, Gu Jiaojiao attempts to curry favor with Dugu Yue to secure a marriage alliance with the Third Prince. Dugu Yue, despising her arrogance, sets an impossible task of collecting manure as a test. Meanwhile, Gu Yunlan uses her new status to protect her mother, Yun’er, from the abusive environment of the Gu household. The story follows Gu Yunlan’s efforts to rebuild her husband’s health, dismantle the corrupt Gu family, and navigate the political intrigue of the imperial court, all while hiding her true identity as a modern medical expert.