Gu Nanyan, a medical genius from modern times, dies in her research lab and transmigrates into the body of a villainess in a CEO romance novel. The original Gu Nanyan was a wealthy heiress betrothed to Shen Suyin, but was manipulated by her so-called best friend Qin Yuwei into breaking off the engagement. Qin Yuwei drugged Gu Nanyan, leading to a one-night stand that resulted in pregnancy and a forced marriage. For four years, Gu Nanyan neglected her son Xiaomumu and obsessively pursued He Yunrui, alienating everyone around her. The story begins on the day Shen Suyin finally agrees to divorce her after she jumped into a lake to force the issue.
Upon waking with the new memories, Gu Nanyan learns of the tragic fate awaiting both herself and her son in the original novel—she would be killed by He Yunrui after he collected insurance money, and Xiaomumu would be driven to mental breakdown and suicide by Qin Yuwei's excessive tutoring. Determined to change her fate, Gu Nanyan immediately refuses to sign the divorce papers, tearing them up in front of Qin Yuwei and declaring her intention to be a good wife and mother. This shocks everyone, particularly Qin Yuwei, whose plans are suddenly derailed.
Gu Nanyan begins transforming her appearance and behavior, dressing elegantly and insisting on eating meals with her family. She confronts Qin Yuwei about the excessive academic pressure being placed on Xiaomumu, who is only three years old but already learning martial arts, violin, calligraphy, and multiple languages. When Xiaomumu chokes on fruit during playtime, Gu Nanyan performs the Heimlich maneuver to save him, but Shen Suyin initially accuses her of poisoning the child. After confirming Xiaomumu is unharmed, Shen Suyin apologizes, marking the first crack in his hostility toward her.
Qin Yuwei attempts to orchestrate a meeting between Gu Nanyan and He Yunrui at the Shen residence, hoping Shen Suyin will witness their reunion and permanently reject Gu Nanyan. However, Gu Nanyan instead publicly beats He Yunrui, declaring her love for Shen Suyin and calling He Yunrui trash. Shen Suyin witnesses this from the shadows, and his attitude toward her begins to shift. That evening, Shen Suyin's mother calls inviting them to visit the family estate, and Xiaomumu explicitly asks for Gu Nanyan to accompany them, showing he has begun to accept her as his mother.
Gu Nanyan also reconnects with her medical expertise, anonymously emailing her brother Gu Nancheng about a difficult medical case he had been struggling with. Her brother, addressing her as "Senior," expresses gratitude and a desire to meet, opening a path for Gu Nanyan to rebuild her family relationships. She begins receiving responses from medical experts worldwide who recognize her knowledge.
The core conflict centers on Gu Nanyan's struggle to overcome four years of damage to her reputation while outmaneuvering Qin Yuwei's schemes. Qin Yuwei continues to manipulate situations, but Gu Nanyan consistently counters her moves, asserting her position as the legitimate Mrs. Shen and Xiaomumu's mother. Shen Suyin remains skeptical but increasingly observant of her genuine changes, particularly noting how Xiaomumu's happiness has improved since Gu Nanyan began spending quality time with him. He ultimately cancels most of the child's excessive courses after Xiaomumu expresses his desire to stop, showing Gu Nanyan's influence is taking effect. The story follows Gu Nanyan's efforts to rebuild trust with her husband and son while using her medical knowledge to establish her own purpose and gradually expose Qin Yuwei's true nature.
