Su Yunzhao, a world-renowned medical expert from the modern era, dies from overwork and transmigrates into the body of an unfavored concubine-born daughter of the Marquis Weiyuan Estate. The original owner had been forced to marry Xiao Jinyao, the Heir Apparent of Prince An Estate, who is terminally ill. Upon waking on her wedding day, Su Yunzhao confronts her abusive brother Su Lu and asserts her authority as the Heir's Consort. She travels to the Prince An Estate alongside Su Yunxiu, her rival sister, who is secretly pregnant with the Second Young Master's child.
At the estate, an elderly maid named Mama Du attempts to humiliate Su Yunzhao by forcing her to enter through the side gate while Su Yunxiu uses the main entrance. Su Yunzhao refuses, draws a weapon, and threatens the servant, ultimately forcing her to allow entry through the main gate. During the wedding ceremony, Xiao Jinyao places the memorial tablet of his deceased mother in the matriarch's seat, disregarding Consort Tian, his stepmother. After the ceremony, Xiao Jinyao suffers a sudden health crisis. Su Yunzhao diagnoses him with accumulated toxins and chronic illness, then successfully treats him using the lost Eight Mystical Needles acupuncture technique in front of Elder Mo, the imperial physician.
The next morning, Consort Tian attempts to infiltrate Su Yunzhao's household with loyal servants. Su Yunzhao rejects them, demanding their deeds of sale to prove they are her people, not spies. She then presents Consort Tian with a white silk stained with Xiao Jinyao's blood, implying she has secured the Heir's favor and potential pregnancy, causing panic in Consort Tian and Su Yunxiu. Later, a servant brings Su Yunzhao contraceptive soup. Su Yunzhao punishes the servant by forcing her to eat the spilled food and threatening her daughter.
Su Yunxiu's maid, Lamei, arrives with a green ceremonial dress intended to humiliate Su Yunzhao. Su Yunzhao has Lamei tied up, slapped twenty times, and dressed in the humiliating gown before being expelled. Xiao Jinyao intervenes, threatening Consort Tian with palace maids to teach etiquette, forcing her to accept Su Yunzhao's actions. Su Yunzhao and Xiao Jinyao are summoned to the palace by the Emperor. At Empress Dowager's palace, she accuses Su Yunzhao of disrespect. Su Yunzhao counters by highlighting her medical success in saving Xiao Jinyao and exposing the abuse she suffered from Consort Tian's servants and Su Yunxiu's maid.
Xiao Jinyao collapses again during the audience. Su Yunzhao stabilizes him with acupuncture. The Emperor then privately asks Su Yunzhao about her background and reveals he summoned her to treat Consort Ru, a favored concubine suffering from a private ailment. Su Yunzhao correctly guesses the condition and is brought to examine Consort Ru, marking her entry into imperial medical circles and solidifying her position within the Prince An Estate.